TAK-243 preferentially sure to UBA1 in excess of the relevant E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lowered amounts of ubiquitylated proteins, greater markers of proteotoxic pressure and DNA injury anxiety. In vivo, TAK-243 lowered leukemic load and targeted leukemic stem cells without evidence of toxi… Read More